醫療團隊

• 輔大醫院神經外科兼任主治醫師

現職

• 花蓮慈濟醫院神經醫學科學中心主任
• 花蓮慈濟大學醫學系副教授
• 花蓮慈濟醫院神經外科主治醫師

經歷

• 台灣神經腫瘤學學會第九屆理事長
• 花蓮慈濟醫院神經外科主任
   
• 花蓮慈濟醫院神經腫瘤科主任
• 中國醫藥學院附設醫院外科加護病房主任
• 中國醫藥學院附設醫院神經外科主治醫師
• 三軍總醫院神經外科主治醫師

• 腦瘤：手術、標靶治療、免疫細胞治療
• 幹細胞治療： 缺血性腦中風、出血性腦中風、脊髓損傷
• 難治神經痛：脊髓損傷、中風後遺症、末梢神經病變

近10年論文發表
1.Chiu TL, Wang MJ, Su CC, The treatment of glioblastoma multiforme through activation of microglia and TRAIL induced by rAAV2-mediated IL-12 in a syngeneic rat model. J Biomed Sci. 2012 Apr 22;19:45. (SCI, IF: 1.96) (IF: 8.410；15/140 =10.71%，MEDICINE, RESEARCH & EXPERIMENTAL)
2.Chiu TL, Tsai ST, Chiu CH. Prediction of flow augmentation and complications of extracranial-intracranial bypass in symptomatic cerebrovascular diseases. J Clin Neurosci. 2012 Jun;19(6):814-9. Epub 2012 Apr 6. (SCI, IF: 1.165) (IF:1.961； 167/208 =80.28%，CLINICAL NEUROLOGY)
3.Wu S-W, Chiu T-L, Chen S-Y, Su C-F, Tsai S-T. Spontaneous disappearance of an acute epidural hematoma with emergence of a contralateral subdural hematoma after traumatic brain injury. Tzu Chi Medical Journal. 2012; 24(3): 139-41.
4.Chiu SC, Huang SY, Chen SP, Su CC, Chiu TL, Pang CY. Tanshinone IIA inhibits human prostate cancer cells growth by induction of endoplasmic reticulum stress in vitro and in vivo. Prostate Cancer Prostatic Dis. 2013; 16(4): 315-22. (IF:5.554； 16/89 =17.98%，UROLOGY & NEPHROLOGY)
5.C. Y. Huang, T. L. Chiu, S. J. Kuo, S. Y. Chien, D. R. Chen, C. C. Su*. Tanshinone IIA inhibits the growth of pancreatic cancer BxPC-3 cells by decreasing protein expression of TCTP, MCL‑1 and Bcl‑xL.  Molecular medicine reports. 2013; 7(3): 1045-9. 
6.Hsin-Yang Huang, Shang-Hsiu Hu, Shih-Ya Hung, Chih-Sheng Chiang, Hao-Li Liu, Tsung-Lang Chiu, Hsin-Yi Lai, You-Yin Chen, San-Yuan Chen*. SPIO nanoparticle-stabilized PAA-F127 thermosensitive nanobubbles with MR/US dual-modality imaging and HIFU-triggered drug release for magnetically guided in vivo tumor therapy. Journal of Controlled Release. 2013; 172(1): 118-27. (IF: 9.776； 23/178 =12.92%，CHEMISTRY, MULTIDISCIPLINARY)
7.Shang-Hsiu Hu T-YH, Chin-Sheng Chiang, Po-Jung Chen, Your-Yin Chen, Tsung-Lang Chiu, San-Yuan Chen*. Surfactant-Free, Lipo-Polymersomes Stabilized by Iron Oxide Nanoparticles/Polymer Interlayer for Synergistically Targeted and Magnetically Guided Gene Delivery. Advanced Healthcare materials. 2013. (IF: 9.933； 8/89 =8.99%，ENGINEERING, BIOMEDICAL)
8.Sheng-Wen Wu*, Chiu T-L. Dissecting aneurysm at the A1 segment of the anterior cerebral artery presenting as visual loss and visual field defect. British Journal of Neurosurgery. 2013; 27(6): 822-3. (IF: 1.596； 162/211 =76.78%，SURGERY)
9.Kuan-Pin Chen, Yu-Cheng Chou, Chia-Fone Lee , Tomor Harnod, Shin-Yuan Chen  , Chain-Fa Su, Peir-Rong Chen, Tsung-Lang Chou*. Prognostic factors of paranasal sinusitis with intracranial invasion: A 14-year review of cases at Hualien Buddhist Tzu Chi Hospital. Tzu Chi Medical Journal. 2016; 28(1): 24-26.
10.Fang J-H, Lai Y-H, Chiu T-L, Chen Y-Y, Hu S-H, Chen S-Y. Magnetic Core–Shell Nanocapsules with Dual-Targeting Capabilities and Co-Delivery of Multiple Drugs to Treat Brain Gliomas. Advanced Healthcare Materials. 2014; 3(8): 1250-1260. (IF: 9.933； 8/89 =8.99%，ENGINEERING, BIOMEDICAL)
11.Huang H-Y, Chiu T-L, Chang H-F, Hsu H-R, Pang C-Y, Liew H-K, Wang M-J. Epigenetic Regulation Contributes to Urocortin-Enhanced Midbrain Dopaminergic Neuron Differentiation. STEM CELLS. 2015; 33(5): 1601-1617. (IF: 6.277； 19/159 =11.95%，BIOTECHNOLOGY & APPLIED MICROBIOLOGY)
12.Shang-Hsiu Hu T-YH, Chin-Sheng Chiang, Po-Jung Chen, Your-Yin Chen, Tsung-Lang Chiu, San-Yuan Chen*. Surfactant-Free, Lipo-Polymersomes Stabilized by Iron Oxide Nanoparticles/Polymer Interlayer for Synergistically Targeted and Magnetically Guided Gene Delivery. Advanced Healthcare materials. 2014; 3(2): 273-282. (IF: 9.933； 8/89 =8.99%，ENGINEERING, BIOMEDICAL)
13.CHIN-CHENG SU, CHIU T-L. Tanshinone IIA decreases the protein expression of EGFR, and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells both in vitro and in vivo. ONCOLOGY REPORTS. 2016; 36(2): 1173-1179. (IF: 3.906； 134/242 =55.37%，ONCOLOGY)
14.TSUNG-LANG CHIU, SU* C-C. SANN- JOONG-KUEY -JIAN –TANG inhibits the migration of human glioblastoma DBTRG cells through decreasing the protein expressions of nuclear factor kappa B (NF-κB), cyclooxygenase 2 (COX 2) and matrix metalloproteinase-2, 7, 9 expression. Sylwan. 2016; 160(6): 231-256. (IF: 0.287； 67/67 =100%，FORESTRY)
15.Chin Cheng Su*, Chiu TL. Sann-Joong-Kuey-Jian-Tang can increase the expression levels of TNF-α, Fas, FADD,Caspase-8, -9 and -3 but decrease Bcl-xL, MCL-1 and TCTP in human hepatocellular carcinoma J5 cells xenograft tumor. Sylwan. 2016; 160(11): 190-211. (IF: 0.287； 67/67 =100%，FORESTRY)
16.Kuan-Pin Chen, Cheng-Chia Lee, Chia-Lin Liao, Tao-Chieh Yang, Tsung-Lang Chiu, Su. C-F. Upfront Gamma Knife Surgery for Giant Central Neurocytoma. World Neurosurgery. 2017; 97: 751.e715–751.e721. (IF: 2.104； 126/211 =59.72%，SURGERY)
17.Chiu TL, Su CC. Tanshinone IIA increases protein expression levels of PERK, ATF6, IRE1alpha, CHOP, caspase3 and caspase12 in pancreatic cancer BxPC3 cellderived xenograft tumors. Mol Med Rep. 2017; 15(5): 3259-3263. (IF: 2.952； 90/140 =64.29%，MEDICINE, RESEARCH & EXPERIMENTAL)
18.Guan-Chyuan Wang, Tomor Harnod, Tsung-Lang Chou, Chen* K-P. Effect of an Anterior Cingulotomy on Pain, Cognition, and Sensory Pathways. World Neurosurgery. 2017; 120: 593-597. (IF: 2.104； 126/211 =59.72%，SURGERY)
19.Lee C-H, Chiu T-L, Tsai S-T, Kuo W-C. Extracranial-intracranial bypass in the treatment of complex or giant internal carotid artery aneurysms. Tzu Chi Medical Journal. 2015; 27: 113-119.
20.Chiu Sheng-Chun, Chiu Tsung-Lang, Huang Sung-Ying, Chang Shu-Fang, Chen Shee-Ping, Pang Cheng-Yoong*, Hsieh Teng-Fu*. Potential therapeutic effects of N-butylidenephthalide from Radix Angelica Sinensis (Danggui) in human bladder cancer cells. BMC Complementary and Alternative Medicine. 2017; 17(1): 523. (IF: 3.659； 6/28 =21.43%，INTEGRATIVE & COMPLEMENTARY MEDICINE)
21.GuanChyuan Wang, KuanPin Chen , ChainFa Su, YenTa Huang, TsungLang Chiu. Neurosurgery for sinusitis-related and sinusitis-unrelated intracranial abscess. Formosan Journal of Surgery. 2017; 50(2): 63-68.
22.Guan-Chyuan Wang ,Kuan-Pin Chen , Tsung-Lang Chiu, Su* Chain-Fa. Treating intracranial dural arteriovenous fistulas with gamma knife radiosurgery: A single-center experience. Tzu Chi Medical Journal. 2017; 29(1): 18-23.
23.Chain-Fa Su*, Dai-Wei Liu, Cheng-Chia Lee, Tsung-Lang Chiu. Volume-staged gamma knife surgery for the treatment of large skull base meningioma surrounding the optical apparatus: A snowman-shape design. Journal of the Chinese Medical Association. 2017; 80(11): 697-704.
24.Liao KF, Chiu TL, Huang SY, Hsieh TF, Chang SF, Ruan JW, Chen SP, Pang CY, SC*. Chiu. Anti-Cancer Effects of Radix Angelica Sinensis (Danggui) and N-Butylidenephthalide on Gastric Cancer: Implications for REDD1 Activation and mTOR Inhibition. Cell Physiol Biochem. 2018; 48(6): 2231-2246. (K.-F. Liao and T.-L. Chiu contributed equally to this work.) (IF: 5.500；8/83 =9.64%，PHYSIOLOGY) 2017 JCR
25.ChienHui Lee, ShengTzung Tsai, Chiu* TsungLang. Superficial temporal artery-middle cerebral artery bypass for the treatment of complex middle cerebral artery aneurysms. Tzu Chi Med J. 2018; 30(2): 110-115. 通訊作者
26.Wang M. J*., Huang H. Y*., Chiu T. L., Chang H. F., Wu H. R. Peroxiredoxin 5 Silencing Sensitizes Dopaminergic Neuronal Cells to Rotenone via DNA Damage-Triggered ATM/p53/PUMA Signaling-Mediated Apoptosis. Cells. 2019; 19(1): 22. (IF: 6.600； 53/195 =27.18%，CELL BIOLOGY)
27.Chang C. Y., Chiu T. L., Chang P. Y., Hu C. M., Wang L. S.*. Subdural effusion and ischemic stroke complicating meningococcal meningitis in an adult. Journal of Microbiology, Immunology and Infection. 2019; 52(1): 165-166. (IF: 4.399； 27/93 =29.03%，INFECTIOUS DISEASES)
28.Chang T. W., Tseng P. H., Wang Y. C., Tseng G. F., Chiu T. L., Lin S. Z., Tsai S. T*. Dopaminergic Degeneration and Small Vessel Disease in Patients with Normal Pressure Hydrocephalus Who Underwent Shunt Surgery. J Clin Med. 2020; 9(4): 1084. (IF: 4.242； 39/167 =23.35%，MEDICINE, GENERAL & INTERNAL)
29.Liao K. F., Chiu T. L., Chang S. F., Wang M. J*., Chiu S. C*. Hispolon Induces Apoptosis, Suppresses Migration and Invasion of Glioblastoma Cells and Inhibits GBM Xenograft Tumor Growth In Vivo. Molecules. 2021; 26(15): 4497. 共同第一作者(IF: 4.412； 63/178 =35.39%，CHEMISTRY, MULTIDISCIPLINARY)
30.Chiu T. L*., Baskaran R., Tsai S. T., Huang C. Y., Chuang M. H., Syu W. S., Harn H. J., Lin Y. C., Chen C. H., Huang P. C., Wang Y. F., Chuang C. H., Lin P. C*., Lin S. Z. Intracerebral transplantation of autologous adipose-derived stem cells for chronic ischemic stroke: A phase I study. J Tissue Eng Regen Med. 2022; 16(1): 3-13. 第一作者  (IF: 3.963； 59/159 =37.11%，BIOTECHNOLOGY & APPLIED MICROBIOLOGY)
31.Lee T. K., Lu C. Y., Tsai S. T., Tseng P. H., Lin Y. C., Lin S. Z., Wang J. C., Huang C. Y., Chiu T. L*. Complete Restoration of Motor Function in Acute Cerebral Stroke Treated with Allogeneic Human Umbilical Cord Blood Monocytes: Preliminary Results of a phase I Clinical Trial. Cell Transplant. 2021; 30: 9636897211067447. 通訊作者 (IF: 4.064； 69/140 =49.29%，MEDICINE, RESEARCH & EXPERIMENTAL)
32.Chiu T. L., Wang Y. J., Chang T. W., Lin S. Z., Tsai S. T*. Granulocyte Colony-Stimulating Factor for Treatment of Patients with Chronic Traumatic Brain Injury: A Preliminary Pre-Post Study. Brain Sci. 2021; 11(11). 第一作者 (IF: 3.394； 157/273 =94.14%，NEUROSCIENCES)
33.Liu Ching-Ann, Liu Wei-Hsiu, Ma Hsin-I, Chen Yuan-Hao, Hueng Dueng-Yuan, Tsai Wen-Chiuan, Lin Shinn-Zong, Harn Horng-Jyh, Chiou Tzyy-Wen, Liu Jen-Wei, Lee Jui-Hao, Chiu Tsung-Lang*. Interstitial Control-Released Polymer Carrying a Targeting Small-Molecule Drug Reduces PD-L1 and MGMT Expression in Recurrent High-Grade Gliomas with TMZ Resistance. Cancers. 2022; 14(4): 1051. 通訊作者  (IF: 6.639； 51/242 =21.07%，ONCOLOGY)
34.Pan Y. H., Lin S. Z., Chiu T. L*. Biodegradable controlled-release polymer containing butylidenephthalide to treat a recurrent cervical spine glioblastoma with promising result: a compassionate trial report. Anticancer Drugs. 2022; 33(4): 394-399. 通訊作者 (IF: 2.248； 209/276 =75.72%，PHARMACOLOGY & PHARMACY)
Liu Ching-Ann, Harn Horng-Jyh, Chen Kuan-Pin, Lee Jui-Hao, Lin Shinn-Zong, Chiu Tsung-Lang*. Targeting the Axl and mTOR Pathway Synergizes Immunotherapy and Chemotherapy to Butylidenephthalide in a Recurrent GBM. Journal of Oncology. 2022; 2022: 3236058. 通訊作者 (IF: 4.375； 115/242 = 47.52%，ONCOLOGY)